Some 330 flights were cancelled by 5:00 pm (1600 GMT) after heavy snow and sub-zero temperatures struck the region around the German financial capital, a spokesman for airport operator Fraport told AFP.
The airport -- Germany's largest air hub and the home base for airline giant Lufthansa -- had been scheduled to handle a total of 1,260 flights over the day.
More flights could be cancelled in the evening, the spokesman said, but added that weather was forecast to improve in the coming hours.
Much of Germany woke up to snowfall and temperatures around zero Sunday.
Elsewhere in the country, Duesseldorf airport was forced to close for four hours during the afternoon, news agency DPA reported.
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