The 56-year-old "Into the Groove" hitmaker said she considers social media an important part of her work, reported Entertainment Weekly.
"I could live without it. But it's an important part of my work now. I like to think of it as a kind of art gallery for my thoughts, my dreams, my wishes, my state of mind. Can't ignore social media," she said.
Madonna said she reads reactions to her posts on Instagram "on holidays" but does not get carried away.
"Sometimes people are really supportive and nice... But you can't get attached to people saying nice things because then when people say mean things it will bother you.
The Grammy Award winning singer however said, people on social media often lack sense of humour.
"The most illuminating thing about reading comments on Instagram is how literal people are, and how people have no sense of humour and no sense of irony... (They) don't read between the lines. It's interesting," she said.