Fey and Poehler set the tone of the evening as they began their monologue with "Welcome you despicable, minimally talented brats" in an apparent dig on how Scott Rudin referred to Angelina Jolie in one of the leaked Sony emails.
They also took pot shots at North Korea as they joked that the evening was a celebration of "all the movies that North Korea was okay with". They also invited Margaret Cho to spoof Kim Jong-un on stage.
They left the audience in shock as they alluded to drug and sexual assault accusations against Cosby by saying that Sleeping Beauty from 'Into the Woods' "just thought she was getting coffee with Bill Cosby".
Fey said North Korea made everyone feel like they cared for 'The Interview' and noted that their criticism of the Seth Rogen-James Franco film was "not the worst review the film got".
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Clooney was again a target of the duo, who said, "So tonight her (Amal's) husband is getting a lifetime achievement award" as they went on to mention the highlights of Amal's career as a human rights lawyer while a bemused actor and his wife watched from the audience.
"We will stand united against anyone who would repress free speech, anywhere from North Korea to Paris," Kingma said.
Clooney, the winner of Cecil B DeMille award, joked that the celebrities were using the night to apologise for all the 'snarky' things they said about one another in hacked emails.
But he turned serious while talking about Charlie Hebdo, "Today was an extraordinary day, there were millions of people who marched not just in Paris but around the world, and they were Christians and Jews and Muslims, they were leaders of countries all over the world and they didn't march in protest.
Clooney also took the opportunity to honour his wife, 36, in a moving speech, calling her the love of his life.
"It is a humbling thing when you find someone to love. Even better if you have been waiting your whole life. And when your whole life is 53 years. Amal, whatever alchemy it is that brought us together, I couldn't be more proud to be your husband," he said.