Researchers have found that slow oscillations in brain activity, which occur during so-called slow-wave sleep is critical for retaining memories.
Playing sounds synchronised to the rhythm of the slow brain oscillations of people who are sleeping enhances these oscillations and boosts a persons memory, they said.
This demonstrates an easy and noninvasive way to influence human brain activity to improve sleep and enhance memory.
"The beauty lies in the simplicity to apply auditory stimulation at low intensities - an approach that is both practical and ethical, if compared for example with electrical stimulation - and therefore portrays a straightforward tool for clinical settings to enhance sleep rhythms," said coauthor Dr Jan Born, of the University of Tubingen, in Germany.
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When the volunteers were exposed to stimulating sounds that were in sync with the brain's slow oscillation rhythm, they were better able to remember word associations they had learned the evening before. Stimulation out of phase with the brain's slow oscillation rhythm was ineffective.
"Importantly, the sound stimulation is effective only when the sounds occur in synchrony with the ongoing slow oscillation rhythm during deep sleep.
"We presented the acoustic stimuli whenever a slow oscillation "up state" was upcoming, and in this way we were able to strengthen the slow oscillation, showing higher amplitude and occurring for longer periods," said Born.
"Moreover, it might be even used to enhance other brain rhythms with obvious functional significance - like rhythms that occur during wakefulness and are involved in the regulation of attention," said Born.
The study was published in the Cell Press journal Neuron.