Although South Africa are overwhelming favourites after comfortable wins in the first two Tests, the match has significance for the hosts and for Amla in particular.
It will be a test of the team culture achieved under the captaincy of Faf du Plessis and an opportunity for Amla to bat his way out of a rare slump in form.
Fast bowler Kyle Abbott shocked Du Plessis, his fellow players and team management during the second Test in Cape Town when he revealed that five months previously he had signed a Kolpak contract to play county cricket in England.
Although uncapped fast bowler Duanne Olivier was called up to join the squad, Abbott's likely replacement is existing squad member Wayne Parnell, a left-arm fast bowler who has had a stop-start career, mainly because of injuries. The most recent of Parnell's four Test appearances was three years ago.
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Parnell was released from the squad during the Cape Town Test and was man of the match for the Cape Cobras franchise, taking six wickets and hitting a century in a win against the Lions.
Amla, by a distance the most experienced player in a team missing injured stars AB de Villiers, Dale Steyn and Morne Morkel, has not hit a half-century in his most recent five Test matches, during which he has scored 195 runs at an average of 21.66.
Amla's career average of 49.46 in nine matches at the Wanderers almost exactly replicates his career average of 49.45. He has hit two of his 25 Test centuries at the ground, most recently against Australia in November 2011.
The tourists have managed just two individual
half-centuries in the first two Tests and captain Angelo Mathews, with 149 runs at an average of 37.25, is the only batsman to have an average above 30.
The Sri Lankan batsmen will need to show a major improvement on a pitch which traditionally offers fast bowlers the most assistance of any of South Africa's Test venues.
Teams:
South Africa (likely): Faf du Plessis (captain), Stephen Cook, Dean Elgar, Hashim Amla, JP Duminy, Temba Bavuma, Quinton de Kock (wkt), Vernon Philander, Wayne Parnell, Keshav Maharaj, Kagiso Rabada.
Sri Lanka (from): Angelo Mathews (captain), Dimuth Karunaratne, Kaushal Silva, Kusal Mendis, Dhananjaya de Silva, Dinesh Chandimal (wkt), Upul Tharanga, Rangana Herath, Suranga Lakmal, Lahiru Kumara, Nuwan Pradeep, Kusal Perera, Dilruwan Perera, Dushmantha Chameera, Vikum Sanjaya.