Baleka Mbete said today that she cut short an overseas trip to deal with the "serious: parliamentary issues" that have arisen since Zuma reshuffled his Cabinet last week.
Mbete said her office received a letter from the main opposition party, the Democratic Alliance, requesting that the national assembly, which is in recess until May 10, resume earlier to vote on the motion.
The request for the motion, which would result in Zuma having to step down if it is passed, must be assessed to see if it is compliant with the parliament's rules, she said.
Zuma has easily survived earlier votes of no confidence. However top ANC members have been vocal in their criticism of Zuma in recent days and they might not support him as before.
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"I must stress that I am alive to the extreme challenges and sense of anxiety our young democracy is going through at this moment," Mbete said. "South Africans are expecting our institutions of democracy such as parliament to demonstrate decisive leadership. This is a responsibility that parliament, for its part, does not take lightly."
Gordhan was seen as a bulwark against corruption and his sacking set off an outcry by anti-Zuma factions in the ruling African National Congress and opposition parties.
Economists say it is likely that South Africa, which saw economic growth of just 0.5 percent last year and has an unemployment rate of around 27 percent, will be downgraded to junk status by credit ratings agencies.
Although the ANC's reputation as the main movement against apartheid has been tainted, it is still seen as the front-runner ahead of general elections in 2019.