A 54-year-old woman died of Middle East Respiratory Syndrome today morning after being diagnosed on June 5, the health ministry said.
It also reported eight new patients including four who had been infected at Samsung Medical Centre in Seoul, considered the epicentre of the outbreak.
This took the total number of infections including those who have died to 162, the largest outbreak outside Saudi Arabia.
Seventeen patients are in critical condition, the ministry said, adding 19 had recovered and been released from hospital.
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But the latest number dashed such hopes, as a health official raised concerns over more new infections beyond the Samsung hospital.
"We think that more new cases can sporadically occur en masse in hospitals other than Samsung," Kwon Joon-Wook, a senior health ministry official, told reporters.
The government aims to curb outbreaks in 11 hospitals considered major epicentres -- including Samsung -- by the end of this month, he added.
Almost all infections so far have been restricted within hospitals.
But several patients diagnosed in recent days were not among those put in quarantine.
One patient reported yesterday in the southeastern city of Daegu developed symptoms on Saturday but continued his normal activities, including going to work and taking a trip to a public bathhouse.