The two join an ensemble that includes Tom Holland as Peter Parker/Spider-Man, Marisa Tomei as Aunt May, and Zendaya in an unknown role, reported Entertainment Weekly.
Michael Keaton is in talks to play a villain in the Sony Pictures and Marvel Studios co-production. Jon Watts is directing the project.
Holland will make his debut as web-slinger next month in "Captain America: Civil War".
"Spider-Man: Homecoming" is slated to hit theaters July 7, 2017.