Even without the injured Dale Steyn and Morne Morkel, South Africa's pace trio of Vernon Philander, Kagiso Rabada and Kyle Abbott is likely to provide a stiff examination of a Sri Lankan batting line-up which has minimal experience of coping with the kind of pitches that are found outside Asia.
St George's Park, though, usually has less pace and bounce than South Africa's other Test venues and the hosts have a relatively modest record there of six wins, four losses and four draws since returning to Test cricket in 1992.
South Africa, meanwhile, will be seeking a strong finish to a year in which there have been three different captains of the Test team.
The year started badly with Hashim Amla resigning as captain midway through a losing home series against England. That loss, which followed a 3-0 humiliation in India late in 2015, cost South Africa their number one ranking in Tests. They slipped as low as seventh after some earlier triumphs were discarded when the ratings were adjusted in May.
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AB de Villiers was appointed captain for the last two Tests against England but a long-term elbow injury ruled him out of home matches against New Zealand and an away series in Australia - both of which were won under the leadership of stand-in Faf du Plessis, enabling South Africa to climb to fourth in the rankings
With De Villiers still not fit enough to face Sri Lanka in the Tests - he is targeting a return in the one-day series which starts in late January - he resigned the captaincy and recommended his former schoolmate as his full-time successor.
Domingo said that despite the difference in conditions from other home venues, "the guys love coming to Port Elizabeth. We feel that the wicket suits us to a degree. The ball tends to reverse swing because of the abrasive wicket. If there is a little bit of an easterly wind or overhead conditions we are able to exploit those conditions as well.
"It's never historically been a fast wicket, it's a wicket where you have to be patient and you have to grind out runs. That's the strength of this particular side, our levels of patience and being able to withstand those types of periods."
South Africa (likely): Faf du Plessis (captain), Stephen Cook, Dean Elgar, Hashim Amla, JP Duminy, Temba Bavuma, Quinton de Kock (wkt), Vernon Philander, Keshav Maharaj, Kyle Abbott, Kagiso Rabada.
Sri Lanka (from): Angelo Mathews (captain), Dinesh Chandimal (wkt), Kusal Mendis, Kusal Perera, Dimuth Karunaratne, Kaushal Silva, Dhananjaya de Silva, Upul Tharanga, Dilruwan Perera, Rangana Herath, Lahiru Kumara, Nuwan Pradeep, Dushmantha Chameera, Suranga Lakmal, Vikum Sanjaya.