The Spider-Man creator, who also created the character of MJ, thinks that the Disney star's take on MJ will be "absolutely wonderful", reported Ace Showbiz.
"If she is as good an actress as I hear she is, I think it'll be absolutely wonderful," Lee said.
The 93-year-old legend said that it would be fine to change a character's physical appearance from the comic book to the big screen.
He recalled and went on to point to the late Michael Clarke Duncan as the Kingpin in Ben Affleck's "Daredevil, The Movie" debuted in 2003.
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Lee noted that a comic book character's physical appearance in the movie was not the most important elements.
"The colour of their skin doesn't matter, their religion doesn't matter. All that matters is that this the right person for the role," he said.
Previously, "Guardians of the Galaxy Vol. 2" helmer James Gunn also defended the casting following the social media backlash from fans.
Zendaya stars alongside Tom Holland in the upcoming solo film which is directed by Jon Watts. The film centers on Holland's Spider-Man who will be back to his high-school roots.