The former champions would start favourites against the visiting side, led by Hanuma Vihari and comprising a mix of experienced players and youngsters.
The home team, led by Abhinav Mukund, would eye for a strong start to the tournament, which is back to the home and away format after the trial of neutral venues concept last season.
Weather would also hold a key with the city receiving rainfall in the past two days.
The hosts boasts of a strong batting line-up comprising M Kaushik Gandhi, who scored heavily in the previous season, the talented young Baba brothers - Indrajith and Aparajith -- and flamboyant wicketkeeper-batsman N Jagadeesan.
More From This Section
If the stylish Vijay, who has been out of the national side since the Australia series owing to injury, gets going at the top with Mukund, Tamil Nadu would be well served.
Ashwin is coming off an impressive performance for Worcestershire in the English County circuit and his inputs could be crucial for the young spinners in the squad including the fast improving M S Washington Sundar.
The pitch at the M A Chidambaram Stadium has usually favoured the slower bowlers.
K Vignesh would spearhead the pace attack which also includes L Vignesh and newcomer V Lakshman while Ashwin leads the spinners also featuring Sundar, Rahil Shah and Malolan Rangarajan.
Tamil Nadu coach Hrishikesh Kanitkar said he was happy with the pre-season preparations adding that the focus would be on playing good cricket.
"We had a good camp in Deharadun where we worked on all the departments and fitness. It was good preparation for the new season," he told PTI.
The Vihari-led side has got a good mixture of youth and experience which includes former India international Y Venugopala Rao. Apart from Rao, DB Ravi Teja and Vijay Kumar were players who would have a big role to play while a bunch of youngsters can infuse energy to the team.
Vihari would hope to lead from the front and expect for solid performances from Rao, the talented Ricky Bhui and B Sumanth.
The bowling unit led by Vijay Kumar and B Ayyappa has its work cut out against a formidable Tamil Nadu batting line-up and holds the key for the team's fortunes.