RCB, on the other hand, have a tricky bowling combination to set right in the absence of injured Australian pace spearhead Mitchell Starc -- ruled out of the season -- and miserly leggie Samuel Badree, who is yet to make an appearance in the T20 league after picking up an injury during West Indies' triumphant run in the World T20 championship.
MI and RCB have fought tooth and nail since 2008 with the IPL result score-line reading 9-8 in favour of the hosts, who have tasted defeat three times in four games this season, including in the last two, in their bid to retain the crown that they won after a similar, poor beginning in 2015.
RCB come into the needle clash after being flattened by South African wicket-keeper batsman Quinton de Kock's masterly hundred, the first ton by any batsman this season, and they will need to quickly correct their bowling combination.
Two-time title winners, MI have slumped to defeats in both their home matches this season -- to IPL debutants Rising Pune Supergiants and Gujarat Lions -- and they would be keen to score their first win on their traditional home ground in one of the two remaining games scheduled at the Wankhede Stadium before they move to Jaipur, which will become their new home for rest of the season.
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But in the other three games, the leading batsmen have failed to click as a unit. Even a re-worked batting order against Sun Risers Hyderabad, by dropping the out-of-form Kieron Pollard from the eleven and making Parthiv Patel open the batting with newcomer Martin Guptill, replacement for their consistent but injured opener Lendl Simmons, did not produce the desired result.
In the absence of their ever-reliance Sri Lankan pacer Lasith Malinga, Mumbai have depended upon the New Zealand duo of Tim Southee and Mitchell McClenaghan to make early inroads and this combination is expected to continue against RCB.
With Englishman Jos Buttler not exactly setting the stage on fire, there could be a case for the big-hitting but yet-to-fire Pollard to regain his spot in the eleven. MI have found in Krunal Pandya, a left-handed spin bowling utility player who can bat well down the order.
But his better known brother Hardik has so far failed to click both with the bat and the ball, although being given a more responsible role, and MI's think tank would be expecting a quick turn-around in performance from this ebullient player.
RCB's obvious might lies in their explosive quartet of top-order batsmen - Chris Gayle, yet to fire his missiles so far, captain Virat Kohli, A B de Villiers and Shane Watson, with fearless Mumbai-based youngster Sarfaraz Khan to follow and end the innings on a flourish.
RCB's troubles lie mainly in their bowling attack in which Watson has been the lone stand-out performer.
New Zealand's quick Adam Milne and South African all rounder David Wiese both leaked runs aplenty in one of the two games they played, but would relish the Wankhede track, which has supported seam bowling this season, if given the chance. Australian pacer Kane Richardson too is waiting in the wings.
The team bowling second here could also be handicapped by the dew factor.
Teams (From):
Mumbai Indians: Rohit Sharma (C), Parthiv Patel, Hardik Pandya, Jos Buttler, Mitchell McClenaghan, Ambati Rayudu, Kieron Pollard, Harbhajan Singh, Jagadeesha Suchith, Tim Southee, Jasprit Bumrah, Shreyas Gopal, R Vinay Kumar, Corey Anderson, Unmukht Chand, Marchant de Lange, Siddhesh Lad, Kishore Kamath, Krunal Pandya, Deepak Punia, Nitish Rana, Jitesh Sharma, Nathu Singh, Akshay Wakhare, Martin Guptill.