The commission co-chaired by former Mexican president Felipe Calderon called for greater global action on renewable power, deforestation and clean technologies as part of the fight against climate change.
The report said that the next 15 years would be critical, with the global economy undergoing major structural changes and time running out to meet a UN-backed goal of checking global warming at 2.0 degrees Celsius (3.6 Fahrenheit) above pre-industrial levels.
"We can invest that amount of money in the current high-carbon emission path or we can do that in a different way," Calderon told reporters on a conference call.
"So the next 15 years of decisions and the next 15 years of investment will determine the future of the world, among other things, in the climate system," he said.
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The report, a year in the making, played down the economic impact of a low-carbon focus. It estimated that greener investment would cost an additional USD 270 billion a year but said the expenses could be offset by lower costs elsewhere, such as reduced spending on fuel.
"It is anchored in an implicit assumption that economies are unchanging and efficient, and future growth will largely be a linear continuation of past trends."
The report said that health and deaths caused by air pollution were a major economic impediment, estimating that top carbon emitter China suffered costs equivalent to more than 10 percent of its gross domestic product.
Governments around the world have faced resistance curbs on carbon emissions, which are blamed for climate change, with opponents citing the economic impact including on jobs in polluting industries such as coal.