His team faces Brazil in a key World Cup qualifier in the northeast Brazilian city of Recife, part of a region at the epicenter of the outbreak of the mosquito-borne virus Zika.
"Suarez should be emotional; should have many things going on in his head after being away from the team," Uruguay coach Oscar Tabarez said.
Suarez will be lining up against Barcelona teammate Neymar in a game that is expected to draw a large crowd of traveling fans from Uruguay.
Ecuador leads South American qualifying with 12 points, three points ahead of Uruguay and five in front of Brazil, Paraguay and Chile.
Also Read
Ecuador will be at home against Paraguay in Quito where it always has a powerful home advantage playing in thin air at 2,850 meters (9,350 feet).
Argentina, the World Cup runner-up two years ago, has only five points and Colombia, which reached the quarterfinals, has only four points.
Argentina has a tough match playing at Copa America champion Chile, which will be under new coach Juan Antonio Pizzi, who replaced Jorge Sampaoli.
In the next series of matches on Tuesday, it is: Colombia vs Ecuador, Uruguay vs Peru, Argentina vs Bolivia, Venezuela vs Chile and Paraguay vs Brazil.