Both adult and adolescent rats were given daily access to sugar-sweetened beverages that mirror sugar concentrations found in common soft drinks.
Adult rats that consumed the sugar-sweetened beverages for one month performed normally in tests of cognitive function; however, when consumption occurred during adolescence the rats were impaired in tests of learning and memory capability.
"It's no secret that refined carbohydrates, particularly when consumed in soft drinks and other beverages, can lead to metabolic disturbances," said the lead author, Dr Scott Kanoski from the University of Southern California.
In addition to causing memory impairment, adolescent sugar-sweetened beverage consumption also produced inflammation in the hippocampus, an area of the brain that controls many learning and memory functions.
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"The hippocampus is such a critical brain region for memory function," said Kanoski.
"In many ways this region is a canary in the coal mine, as it is particularly sensitive to insult by various environmental factors, including eating foods that are high in saturated fat and processed sugar," Kanoski said.