The suicide bomber targeted the headquarters of local Taliban commander Mullah Nabi Hanafi in Orakzai Agency.
Hanafi was not present at the time of the attack.
Gunmen first fired shots at the compound and then the suicide bomber detonated his vehicle.
The building collapsed due to the explosion and the compound was badly destroyed.
Hanfi was the commander of the Hangu chapter of the Tehreek-e-Taliban Pakistan (TTP) before switching sides and joining the government's counter-insurgency efforts, The Express Tribune said.