The 31-year-old actor will feature in the movie, which traces the life of a young girl suffering from cancer, who subsequently meets a boy at a support group and falls in love with him.
Sushant will play Ensel Algort's character, Gus, a cancer survivor who falls for the terminally-ill Hazel (originally played by Shailene Woodley).
The film also marks the directorial debut of casting director Mukesh Chhabra.
Confirming the news, Chhabra said he is currently working on the script of the movie and the team is on the look-out for its female lead.
The remake will be produced by Fox Star Studios and will begin shooting in the first half of next year.
Based on John Green's novel, the original movie was directed by Josh Boone.