The Syrian Observatory for Human Rights said strikes on Wednesday had killed 29 civilians, including nine women and three children, in villages controlled by the Islamic State group in the eastern Deir Ezzor province and its provincial capital of the same name.
The strikes killed another 15 civilians, including five young brothers, in and around the city of Al-Bab, an IS bastion in the northern province of Aleppo, the Observatory said.
Ten more civilians, including seven children, were killed in Russian strikes in Ghanto, a town held by Islamist rebels in the central province of Homs, it said.
Russia launched air strikes in Syria in September in support of President Bashar al-Assad's regime, a key ally. The US-led coalition has been carrying out strikes against IS targets in Syria and Iraq since the summer of 2014.
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Russian backing has helped Assad's forces make significant advances in recent months and the Observatory said Thursday that regime troops had moved to within eight kilometres (five miles) of Al-Bab.
Al-Bab, about 30 kilometres (20 miles) south of the Turkish border, fell to rebel forces in July 2012 and was taken over by IS in November 2013.
Regime forces are seeking to sever IS-held territory in Aleppo province from that held by the group in neighbouring Raqa.
The Observatory said last week that Russian strikes in Syria had killed more than 1,000 civilians, including around 200 children, since September.
Russia has denounced accusations that its raids have killed large numbers of civilians as "absurd".