The 32-year-old actor plays astrophysicist Rajesh Koothrappali in the comedy show, reported People magazine.
"Ryan Sweeting is a great guy and I know he's going to take great care of her. I think they both complement each other really well," Nayyar said.
"I think the beauty of their relationship is they don't take anything too seriously. They're always laughing, which is really important in a marriage. Hopefully they'll keep each other in check," he added.
Cuoco tied the knot with Sweeting on New Year's Eve in a fire-and-ice-themed ceremony.
"Kaley is like a sister to me. You become so close over such a long period of time. It's like your family member getting married," he said.