Laboratory tests confirmed that the virus killed a 62-year-old man, who died Saturday in a hospital in Cantabria, the regional government said.
A 76-year-old victim, who had been suffering from other unspecified diseases, died at a hospital in Zaragoza in the region of Aragon where he was being treated for the H1N1 virus, a government spokeswoman for the region said yesterday.
Another 43 people who have tested positive for the H1N1 flu virus are receiving treatment in hospitals in Aragon, including 18 who are in intensive care, she added.
The World Health Organisation declared the swine flu pandemic over in August 2010, more than a year after the H1N1 virus that emerged from Mexico sparked panic and killed thousands of people around the world.