The drive-in, in a former industrial zone in the west of the city, has a track where the sex workers can show off their assets and negotiate a price, and nine so-called "sex boxes" where they and their clients can park and conclude the transaction.
When it opens at 7:00 PM (1700 GMT) today, the downtown street of Sihlquai, where barely-dressed street-walkers have long openly and sometimes aggressively plied their trade to the dismay of residents and businesses, will become off-limits to prostitution.
However, some prostitutes have voiced concern that the strictly controlled environment of the drive-in would scare off their customers, and Zurich police said it remained unclear whether they and their clients would agree to the move.
"That is the big question. We have no idea how many women will show up," police spokesman Mario Cortesi told AFP.
More From This Section
The new sex drive-in was approved by 52.6 percent of Zurich voters in a March 2012 referendum.
"Because if we do not control it, organised crime is taking over, and the pimps are taking over," he told AFP.
Cortesi said around 100 women had recently been working Sihlquai, adding that if the prostitutes do not want to go to the new drive-in there are two other sites in Zurich where they can legally work.
He said some 1,200 women -- mainly from Eastern Europe -- registered as sex workers last year in Switzerland's largest city. But since only newcomers to the trade are listed and many likely work illegally, the true number of prostitutes in the city remains unclear.
Kocher stressed the dangers of street prostitution, pointing out that clients can drive anywhere with the prostitutes, who have no protection if the situation turns violent.