A team of first responders, the Syrian Civil Defense in Idlib, said 22 people were killed and at least 50 wounded in the raids on the village of Hass. Most of those killed were children, the group said in a posting on its Facebook page.
Another activist group, the Britain-based Syrian Observatory for Human Rights, gave the same death toll and said 14 children and a woman were among those killed.
Idlib is the main Syrian opposition stronghold, though radical groups also have a large presence there. It has regularly been hit by Syrian and Russian warplanes as well as the U.S.-led coalition targeting Islamic State militants.
Footage posted by activists online shows a huge plume of smoke rising from the area of the strikes and rescuers rushing casualties away along a dusty road lined with destroyed buildings.
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An activist at the scene, Muaz al-Shami, said as many as 10 airstrikes were believed to have hit the residential area. The video content couldn't be independently confirmed.
However, it conforms with AP reporting on the events depicted.
Earlier in the day, the northern Aleppo province saw a new escalation as a helicopter believed to belong to Syrian government forces dropped barrel bombs in a deadly attack on Turkey-backed opposition forces in the border area, Turkish officials said.
The barrel bombing was said to have occurred in the village of Tal Madiq, in a part of northern Aleppo where rival groups have been operating, mostly to rout Islamic State militants.
If confirmed, it would be the first attack by Syrian government forces on the Turkish-backed fighters. Turkey's state-run news agency didn't say when the attack occurred and said at least two Syrian opposition fighters were killed and five others wounded. A Syrian opposition spokesman said it took place yesterday.