"The Syrian republic condemns in the strongest terms the cowardly terrorist attack that led to the death of the Russian ambassador in Turkey, Andrei Karlov," a ministry statement said.
"This despicable crime confirms once again the urgent need to expand all efforts and means to fight and eliminate terrorism," it added.
Russia is Syria's main ally in the nearly six-year war, and has helped President Bashar al-Assad's forces to retake the battleground northern city of Aleppo from rebels.
The gunman who shot Moscow's envoy at an art exhibition in Ankara shouted "Aleppo" and "revenge", a witness said.
Ankara mayor Melih Gokcek has identified the shooter as a Turkish policeman.
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