"On Syria, I'm unfortunately rather pessimistic," Fabius said yesterday.
"The moderate opposition that we support is in serious difficulty," he said, voicing "doubts" over the prospects of peace talks known as "Geneva 2" that mediators have been trying to organise to negotiate an end to the conflict.
The talks are scheduled for January 22 in the Swiss city, but Fabius said there were "doubts" over whether they would make progress toward ending the civil war that has now raged for more than two and a half years and killed more than 126,000 people.
Fabius was speaking in Monaco as he left the World Policy Conference, a meeting of political and business leaders.
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The Free Syrian Army, the moderate rebel group supported by Western powers including France, has been losing ground to Islamist fighters as the insurgency against President Bashar al-Assad has turned into a more complex conflict with schisms between the various rebel groups.
The opposition wants the Geneva peace conference to unseat Assad, but his regime has refused to accept any preconditions on the talks.