Since it broke out in March 2011, Syria's conflict has killed more than 320,000 people, displaced millions and ravaged the country's economy and infrastructure.
Efforts to end the war are now proceeding along two rival tracks: the formal political peace process hosted at United Nations headquarters in Geneva and, since January, parallel talks in Kazakhstan brokered by Russia, Iran and Turkey.
Observers say the UN appears to be scrambling to match Astana's momentum after a landmark deal signed in Kazakhstan on May 4 that would create four "de-escalation" zones across some of Syria's bloodiest battlegrounds.
But in Damascus, which is not included in the deal, the government has secured the evacuation of three rebel-held districts, bringing it closer to exerting full control over the capital for the first time since 2012.
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Briefing journalists last week in Geneva, UN special envoy Staffan de Mistura stressed the "rather business-like, rather short" nature of the upcoming talks, expected to last just four days in order to "hit the iron while it's hot".
"After the Astana meeting which took place and which we attended proactively, there has been some outcomes that we find extremely, potentially, promising and we want to connect, as much as possible, that outcome with some political horizon," de Mistura said.
Aron Lund, a fellow at The Century Foundation, said that despite Geneva's important "symbolic value, it isn't moving forward in any visible way."
"In practice, the Geneva track has largely been sidelined by the Astana track, at least for now," Lund said.
Delegations are expected to arrive in Geneva on Monday, a day before the talks start.
The Syrian government team will be headed once again by its ambassador to the United Nations, Bashar al-Jaafari.
The HNC has continued to call for the ouster of President Bashar al-Assad as part of a political transition, a demand seen as a non-starter by the Syrian regime.
"By design, the Geneva process revolves around this dead-end demand for a negotiated transition," Lund told AFP.
"In terms of actually trying to stabilise Syria, the main effect of pegging peace to transition has been to marginalise the UN in Geneva and shift attention to Astana instead," he said.
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