"The losses in the industrial sector from the start of the Syrian crisis till October total USD 2.2 billion," the pro-regime newspaper Al-Watan quoted Tohme as saying.
The private industrial sector has lost USD 1.5 billion, while public industry has lost USD 700 million, he said.
But he insisted that the figures did not reflect losses incurred in parts of the country held by rebel groups fighting to topple the regime.
More than 120,000 people have been killed in Syria's war, and millions more forced to flee their homes.
According to the UN, more than half the Syrian population is now living in poverty.