Damascus would abide by the agreement signed in the Kazakh capital of Astana last week, Walid al-Moallem told reporters at a news conference in the Syrian capital, but cautioned it was "premature" to tell whether the deal would succeed.
"There will be no presence by any international forces supervised by the United Nations," al-Moallem said. "The Russian guarantor has clarified that there will be military police and observation centers."
Al-Moallem also vowed that Syrian government forces would respond "decisively" to any violation or attack from the opposition's side.
"There are still logistical details that will be discussed in Damascus and we will see the extent of commitment to this agreement," al-Moallem said.
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The Russia-Iran-Turkey cease-fire deal went into effect over the weekend and brought a general reduction in violence across the country, but clashes continued, particularly in central Syria. There are still questions about how it will be enforced.
The United States is not party to the de-escalation agreement. US Defense Secretary Jim Mattis said the US owes it to the people of Syria to take a close look at the proposal for "safe zones" in Syria. But Mattis also said the plan poses many unanswered questions, including whether it would be effective.
Speaking to reporters traveling with him to Copenhagen, he suggested that it's still not yet clear what impact the plan could have on the US-led fight against Islamic State group militants.
For his part, al-Moallem said the government hopes the agreement will, as a start, achieve a separation between Syrian armed opposition groups and extremist groups such as the al-Qaida branch in Syria.
"It is the duty of these armed groups to force the Nusra Front (al-Qaida branch) and others to leave their areas in order for this area to become an area of de-escalation," he said.
Al-Moallem also warned neighboring Jordan not to send troops to Syria, adding that Damascus does not want confrontation but "if Jordanian forces enter our land without coordination with Syria, we will consider them hostile forces."
The Syrian foreign minister also suggested the government forces' next target is Deir el-Zour, where IS militants are besieging parts of the eastern city that are under government control and are home to tens of thousands of people.
Al-Moallem said the Syrian government's alternative to stalled negotiations has been the implementation of "reconciliation agreements" around the country.
Such agreements have seen the surrender of rebel-held areas to government forces and their allies on the ground, often after a prolonged period of siege in exchange for safe relocation to opposition-held areas elsewhere in the country.