The evacuation from Damascus' northeastern Barzeh neighborhood is the first such population movement in this area.
Over the past months, tens of thousands of people living in besieged areas around Damascus, Homs, and Aleppo Syria's largest city have surrendered after prolonged sieges in exchange for safe relocation to opposition-held areas elsewhere in the country.
The Britain-based Syrian Observatory for Human Rights said hundreds are expected to leave Barzeh to head to the country's north. It says around 1,500 are expected to leave today and more stages will follow in coming weeks.