The bombing occurred as worshippers left the Bilal al-Habshi mosque on the edge of Akrama after attending Friday prayers, the TV said.
The area, populated mainly by Alawites, members of President Bashar Assad's minority sect, repeatedly has been targeted by car bombs in recent months.
Opposition activists also reported the blast. The Syrian Observatory for Human rights said the explosion killed at least nine people, adding that the number likely would rise because many of the wounded were in critical condition.
Homs is the last major stronghold for rebels in central Syria, and the fight to take it underscores how emboldened Syrian forces have become in opposition-held areas, bolstered by fighters from the Lebanese Shiite militant group Hezbollah.
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Activists say more than 150,000 people have been killed in the Syrian conflict since it began in March 2011 with largely peaceful protests calling for Assad's ouster.
In an audio message posted on militant websites yesterday, the spokesman of a powerful al-Qaeda breakaway group, the Islamic State of Iraq and the Levant, slammed the terror network's chief, blaming him for the widening rift between rival Islamic rebels.
Abu Mohammed al-Adnani accused al-Qaeda's top leader, Ayman al-Zawahri, of "deviating from the right approach" and betraying the cause of jihad, or holy war.
Since January, the Islamic State has been engaged in fierce fighting against an al-Qaeda affiliate called the Nusra Front. Thousands of fighters have been killed.
"The al-Qaeda of today is no longer the al-Qaeda of jihad, but its command has become a pickaxe to demolish the Islamic State," al-Adnani said.
He said that al-Qaeda's leadership has been calling ISIL followers renegades without a proof, inciting other Muslims to kill their fighters.
The shadowy al-Adnani is one of the world's most feared terrorists, infamous for his relentless bombing campaigns against Iraqi civilians, audacious jailbreaks of fellow militants and for expanding the organization into Syria.