The push on Deir Hafer comes as U.S. Aircraft ferried Syrian Kurdish fighters and allies behind IS lines to spearhead a major ground assault on the strategic IS-held town of Tabqa in Raqqa province, which borders Aleppo.
That airlift marked a deepening U.S. Involvement in Syria's conflict ahead of a looming battle for the extremist group's de facto capital, the city of Raqqa.
The airlift was part of what Pentagon spokesman Eric Pahon described as a large, high-priority offensive to secure the area around Tabqa and the associated Tabqa Dam.
"It has become a military base to launch our operations on the west bank of the river until eventually liberating all the countryside of Raqqa," the statement said.
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Tabqa lies 45 kilometers (28 miles) west of Raqqa. The Islamic State group controls the town as well as the Tabqa Dam on the Euphrates River which supplies electric power to the area and a military airfield nearby.
The Syrian Central Military Media says Syrian troops launched the Deir Hafer siege late yesterday after capturing nearby areas.
The opposition's Britain-based Syrian Observatory for Human Rights says Syrian troops have now cut the road linking Deir Hafer with Raqqa province.
The Observatory also reported intense clashes in the central province of Hama, where insurgent groups spearheaded by al-Qaida's branch in Syria launched a wide offensive capturing dozens of villages and towns over the past two days.
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