The "Giants" hitmakers and popular girl group will headline the two-day event to be held at Otterspool Promenade on September 2 and 3, reported Contactmusic.
"Touch" hitmakers Little Mix - Perrie Edwards, Jesy Nelson, Jade Thirlwall and Leigh-Anne Pinnock said, "We're really excited to be headlining Fusion Festival with absolute legends, Take That. We can't wait to see all our fans up in Liverpool for what we know will be a sensational weekend of live pop music."
They will be joined by Tinie Tempah, "Love Me Again" singer John Newman, Louisa Johnson and "X Factor" favourites 5 After Midnight on September 2.
They will be supported by Ella Henderson, The Vamps, JP Cooper and DJ-and-producer Jax Jones on Sunday September 3.