The Improvised Explosive Device (IED) blast took place outside the house of the Tehrik-e-Taliban Pakistan (TTP) commander, known as Khabare, in Mehraban Kalay area of Tirrah Valley in Khyber Agency, sources said.
No one has claimed responsibility for the attack.
In another incident, a truck driver and a cleaner were killed when unidentified militants attacked a NATO tanker in Jamrud tehsil area of Khyber Agency.
The tanker was transporting goods for NATO forces in Afghanistan when it was attacked on Pak-Afghan highway.