The deadly rocket attack on Bagram, Afghanistan's biggest US-led military base just north of Kabul, was a stark reminder of the potency of an Islamist insurgency that has time and again hit major targets.
Prior to the Bagram attack, US President Barack Obama had welcomed the planned talks in Qatar as an "important first step". But he warned of a bumpy road ahead as NATO troops enter the final stage of a 12-year foreign intervention.
"Four soldiers are dead and six others are wounded. The rockets caused a major fire."
A US defence official confirmed that four Americans were killed in the attack, but provided no further details.
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The Taliban broke off contact with the Americans last year and have always refused to negotiate with Kabul. Yesterday, they unveiled an office in Qatar "to open dialogue between the Taliban and the world". Their statement, however, made no direct reference to peace talks.
A divided insurgency is also likely to complicate talks, amid doubts as to whether the "Haqqani network" of warlord Jalaluddin Haqqani, a former CIA asset turned Al-Qaeda ally, is ready to embrace negotiation.
A Taliban spokesman in Qatar, Mohammad Sohail Shaheen, confirmed before the Bagram strike that the armed group would continue to attack US targets in Afghanistan at the same time as holding any talks.
Obama insisted the Taliban would have to renounce ties to Al-Qaeda, halt violence and commit to the protection of women and minorities. He warned that US-led NATO forces remain "fully committed" to battling Al-Qaeda.
"An Afghan-led and Afghan-owned peace process is the best way to end the violence and to ensure lasting stability in Afghanistan and the region," Obama said on the sidelines of a G8 summit in Northern Ireland.