Diplomats from the World Trade Organisation's 159 members had been trying to forge an agreement before a trade ministers' meeting next week in Bali, Indonesia. Achieving a deal in Bali is seen as a final effort to revive a broader 12-year effort to ease global trade rules.
The mini-deal discussed in Geneva had been intended, in part, to reduce delays and inefficiencies at national borders.
Making it easier to move goods across borders could boost the global economy by nearly USD 1 trillion a year and support 21 million jobs, according to a report co-written by Jeffrey Schott, a senior fellow in international trade at the Peterson Institute for International Economics.
"This should be a no-brainer for developed and developing countries," Schott said.
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Deputy US Trade Representative Michael Punke expressed "a great deal of sadness" over the failure in Geneva.
"We're worried alongside so many in this room that a once-in-a-generation opportunity may have slipped our grasp," Punke said.
Schott said he's hopeful that negotiators will salvage the deal in Bali and restore the efforts to achieve a broader trade agreement.
Some poor countries are demanding economic and technical assistance before they sign on. India is holding up a deal by insisting on protections for its farmers.
The WTO chief, Roberto Azevedo, said so much disagreement remains that several more weeks of negotiations cannot bridge the gaps.
"Holding negotiations in the short time we'll have in Bali would be simply impractical with over 100 ministers around the table," Azevedo said.