At stumps on the second day, Tamil Nadu were 218/4 in 75 overs, trailing by 66 runs at Vidarbha Cricket Association Ground.
Resuming on 241/6, Punjab added 43 runs for the loss of four wickets, with overnight batsman Gitansh Khera remaining unbeaten on 40.
Medium pacers Krishnamoorthy Vignesh (4/104) and A Aswin Crist (3/73).
In reply, Tamil Nadu lost skipper Abhinav Mukund and Laxmesha Suryaprakash with 44 runs on the board.
But an 85-run partnership for the fourth wicket between Kaushik Gandhi (75 not out) and the experienced Dinesh Karthik (54) steadied the TN innings. After Karthik's departure made it 156/4, Gandhi put on 62 runs for the fifth wicket with Vijay Shankar, who was batting 32 at close of play.
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