Opting to bowl after winning the toss, Tamil Nadu restricted Hyderabad to 140 for eight in the stipulated 20 overs.
In reply, Tamil Nadu completed the chase with eight balls to spare at the Vidarbha Cricket Association Stadium in Jamtha.
Jaweed Ali top-scored for Hyderabad with 35 off 19 balls, hitting six boundaries.
For Tamil Nadu, Murugan Ashwin picked up three wickets for 18 runs in his quota for four overs.