The donation will be used for setting up a new facility at its campus in Pittsburgh, Pennsylvania and providing scholarships for students.
"Representing the largest corporate gift to CMU and the largest gift from outside the US, this donation will fund a new facility, the TCS Building, which will support education and cutting-edge research by CMU faculty and students," CMU said in a statement.
The building will also provide space for TCS staff to interact with CMU faculty, staff and students, it said.
The Pennsylvania Governor, Tom Wolf, welcomed the donation and said, "This is an exciting time as we see more and more companies establish and expand their presence in the state."
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Carnegie Mellon has been especially adept in attracting cutting-edge businesses to and near its campus, which helps to drive economic growth, he added.
The statement further said, the gift will also endow Presidential Fellowships and Scholarships, increasing access to a CMU education for outstanding students.
"Together, our two organisations have the capabilities and capacity to make breakthrough discoveries, and the scale to make societal impact on a global scale," he said.