He was 72.
Brahmanaih is survived by a son and three daughters. He had been undergoing treatment for a lung disease from the last two months, they said.
Influenced by the TDP founder NT Rama Rao, Brahmanaih had been actively involved in the party affairs since its inception in 1982.
He was elected as a legislator from Machilipatnam assembly constituency in 1994 on TDP ticket and later elected as a member of Parliament in 1999.
However, after losing the 2004 general elections, he again joined the state politics and won the Avanigadda assembly seat in 2009.