The discovery led by University of Florida geology researcher George D Kamenov could help police solve cold cases.
For instance, if an unidentified decomposed body is found, testing the lead in the teeth could immediately help focus the investigation on a certain geographic area.
That way, law enforcement can avoid wasting resources checking for missing persons in the wrong places.
"We can use this pollution signal to figure out where these people came from," he said.
Lead is composed of four variants, called isotopes. The amount of those isotopes fluctuates in different rocks, soils and ores - and, therefore, regions of the world.
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Tooth enamel, which develops during childhood, locks in the lead signals and preserves them.
"When you grow up, you record the signal of the local environment. If you move somewhere else, your isotope will be distinct from the local population," Kamenov said.
Even different teeth can reveal certain facts.
First molar enamel is finished forming by age 3, so it provides information about birth and toddler years.
Lead analysis can also tell what time period a body is from.
Modern and historical teeth have different signals, according to the study. The natural composition of lead changed over the past century because of mining and the use of leaded gasoline, so there's a clear distinction between modern and historical human exposure.
Using that information, archaeologists can identify early European bodies in New World areas.
The study was published in the journal Science of The Total Environment.