Down 12/1 in the seventh over, Kerala rode on a huge 234-run partnership between Thakkar (120 batting; 16x4) and Prem (117; 14x4) to close day one on 290/2.
Giving Prem company was Sanju Samson on 28 at stumps.
Fresh from their win against Chhattisgarh, Goa started on a positive not when Rituraj Singh (1/21) dismissed Vishnu Sood but they found the going tough with Thakkar and Prem putting up a fine partnership.
Kerala 290/2; 90 overs (Rohan Prem 120 batting, Bhavin Thakkar 117) vs Goa.