The new James Bobin-directed film, featuring Tina Fey and Ricky Gervais, was previously named as "The Muppets... Again!", reported Ace Showbiz.
While not much has been revealed abut the film's plot, it draws the fuzzy gang into the world of international espionage, with the majority of shooting taking place in the UK.
The 2011 film's main duo of Jason Segal and Amy Adams are not returning.
"Muppets Most Wanted" will open on March 21, 2014.