The renewal indicates the series from Al Jean and Matt Groening will extend through season 28, said the Hollywood Reporter.
This marks the latest multi-season renewal for TV's longest-running hit.
Following prolonged negotiations with its voice cast, the network reached new deals and picked up the show for two additional seasons in 2011.
With the additional season order, the animated family comedy following the misadventures of Homer, Bart and company will reach a staggering 625 total issues.
The early pickup also means there will be no interruption in the show's production process.