Mirren, 70, said the "profound sexism" is still present in Hollywood today which prevents older women from scoring more movie roles, reported Daily Telegraph.
When asked if the acting industry less accepting of older women, Mirren said, "There is profound sexism... On the cinema screen, your face is 10ft high and 6ft wide. It's huge.
"I, as a cinemagoer, like to see beautiful faces up there - it's a pleasure. But there's also story and entertainment, and one wants variety in that. You also want, as an audience member, to see people that you recognise and can identify with."
"When roles for women in real life change, then you will see change in the film industry. If we happen to see a (female) president of the United States, and a world expert on marine biology comes on television and it's a woman, or the female head of a petroleum company on the news.