A soyem is a three-day Islamic rite held after burying the deceased.
Quran Khawani and prayers were held since morning for the departed humanitarian who passed away at the age of 92 on Friday night after a prolonged battle with renal failure.
"Hundreds of people including some politicians and celebrities have shown up today for the soyem," his son, Faisal Edhi said.
"There are tight security measures for the soyem in and outside theMemon mosque," he added.
Edhi was given a state funeral by the government yesterday at the National stadium and laid to rest at the Edhi village. His funeral was attended by tens of thousands of people including President Mamnoon Hussain and army chief General Raheel Sharif.
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"The roads in and around the mosque are also closed for traffic," he added.
The Memon mosque is located in the old area of Karachi near Kharadar and Bolton Market where Edhi launched his first welfare home for the poor, needy and destitute in 1951.
The country has been in a state of mourning since Edhi's death with shopping centres and markets largely remaining closed on Sunday as well.
Ateeq ur Rehman who heads the all Karachi traders association said majority of the markets and shopping centres were closed as a mark of respect for Edhi.
Edhi, who had dedicated his life to humanity and serving the poor, was widely respected in Pakistan due to his humanitarian and social welfare works.
Edhi foundation had taken care of Indian girl Geeta during her over a decade-long stay in Pakistan. Geeta, with speech and hearing impairments, was about 11 years old when she is believed to have accidentally crossed over to Pakistan and returned in India in October last year.
Not only in Pakistan where the Edhi ambulance service is the largest free network for the needy and poor, philanthropist Edhi received accolades for his work from India, Bosnia, Lebanon and Myanmar as well.
Sindh government has announced three days of mourning to be observed in the state where Edhi had migrated from Gujarat after India's partition in 1947.