The 200-kilogram bombs are thought to have been dropped by US warplanes in February 1970 against communist forces on Cambodia's southeastern border with Vietnam.
Heng Ratana, director general of the Cambodian Mine Action Center (CMAC), said villagers, including 200 students, will have to be evacuated before deminers move into the village in Svay Rieng province.
"We will have to evacuate students because the bombs contain chemical and explosive substances," he told AFP.
The bombs are believed to be among a total of four pieces of ordnance dropped over the province by US warplanes in February 1970.
More From This Section
Locals told CMAC that two of the bombs exploded and damaged a Buddhist dinning hall in the province at the time.
Nearly three decades of civil war starting in the 1960s left Cambodia, along with neighbouring Laos, one of the most heavily bombed and mined countries in the world.
Unexploded ordnance has killed nearly 20,000 people and maimed tens of thousands of others since 1979, according to official estimates.