Prime Minister Binali Yildirim blamed the attack on the "killer PKK", referring to the outlawed rebel Kurdistan Workers' Party.
"We will fight them both in urban centres and rural areas with determination," he vowed.
Turkey remains on high alert after multiple attacks on its soil that have killed well over 200 people in the past year and have been blamed on, or claimed by, Kurdish militants and Islamic State (IS) jihadists.
The windows of houses in the neighbourhood were shattered by the force of the blast.
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Yildirim said one police officer and two civilians have been confirmed dead so far while 30 people were injured.
The police station blast comes a day after a bombing in the heart of Istanbul killed 11 people, including several police, the latest in a spate of attacks in Turkey's largest city.
The government today put the toll at six officers and five civilians.
A radical splinter group of the PKK, the Kurdistan Freedom Falcons (TAK), claimed responsibility for two bombings in Ankara earlier this year that killed dozens of people.
Violence flared last year between Kurdish rebels and government forces, shattering a 2013 ceasefire reached after secret talks between PKK leader Abdullah Ocalan and the Turkish state.
Turkey has been waging an intense offensive against the PKK, deploying tanks in several towns in the southeast in recent months to "cleanse" them of rebel elements.
But the government says the operations are essential for public safety, blaming the PKK - listed as a terror group by Ankara and its Western allies - for the damage.
Over 40,000 people have been killed since the PKK took up arms in 1984 demanding an independent state for Kurds. Since then the group has narrowed its demands to greater autonomy and cultural rights.