The trio, Saran Prembabu, Shashwat Kishore and Anvita Gupta yesterday won medals at the competition, however none of the three could get the top award, which has been dominated in previous years by Indian-Americans.
Noah Golowich, Andrew Jin and Michael Hofmann Winer, each received the first-place award of USD 150,000 at the Intel science competition, a program of Society for Science & the Public, the organisers said.
Saranesh (Saran) Thanika Prembabu, 17, of San Ramon, California, won the Second Place Medal of Distinction for Innovation.
Saran studied how varying the layers of lead titanate and strontium ruthenate in nanocrystal superlattices could affect their electrical and magnetic properties, which could be harnessed for a variety of electrical and computing applications.
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Shashwat Kishore, 18, of West Chester, Pennsylvania, won the Third Place Medal of Distinction for Basic Research.
Shashwat's math project focused on representing abstract algebras using matrices.
Anvita Gupta, 17, of Scottsdale, Arizona, won the Third Place Medal of Distinction for Global Good.
Pre-clinical trials are already underway in China on the tuberculosis drug that she identified.
"We are honoured to congratulate Noah, Andrew, Michael and the rest of the top winners of the Intel Science Talent Search 2015," said, Maya Ajmera, President and CEO of Society for Science & the Public and alumna of the Science Talent Search.
"These students serve as shining examples of the incredible work being accomplished in STEM fields by young people, and we are proud to recognise and reward these stellar young researchers," she said.