ISS commander, Russia's Maxim Surayev, his American colleague Reid Wiseman and German Alexander Gerst from the European Space Agency touched down today.
The three men smiled broadly from reclining chairs as medical personnel tended to them amid patches of snow on the barren steppe just northeast of Arkalyk, Kazakhstan, where they landed.
Surayev flashed a V for victory sign while Wiseman pumped his fist as they waited to regain their land legs after nearly half a year of weightlessness.
"Let's try to live together side by side. This is the most important thing," he added.
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While in space the crew traveled more than 70 million miles (112.7 million kilometers), NASA said.
The "bulls-eye" touchdown was executed amid low clouds and fog "following a flawless descent back into the atmosphere," according to NASA TV.
The spacecraft was pulled onto its side by its parachute upon arrival, which NASA TV added was not uncommon.
The US space agency said the "departure of Wiseman, Gerst and Surayev marks the end of Expedition 41," referring to their mission to the ISS to carry out equipment repairs, maintenance and experiments.
The three men were pictured smiling and with their arms around each other before hitching the ride back home, undocking from ISS at 7:31 pm (0031 GMT).
Another three-person crew remains on the ISS to "continue research and maintenance aboard the station" and will be joined by three more astronauts who launch from Kazakhstan on November 23, NASA said.
NASA lost its ability to reach the space station when the shuttle program ended in 2011 after 30 years.
In the meantime, the world's astronauts must rely on Russia's Soyuz spacecraft to get to the ISS and back, at a cost of USD 70 million per seat.