The accident happened near Dudley Road just outside the Kilgore city.
The family -- husband, wife and their two children -- were travelling through the area in a minivan when they spotted a oil field truck coming towards then from the wrong direction.
The father of the children tried to take evasive action, but ended up striking the truck. Two children, 6-year-old Ryera Patel and 12-year-old Trish Patel, were killed on the spot, the News-journal reported.
Shelby Taylor, 22, a Henderson resident, the driver of the truck involved in Thursday's crash was later arrested and charged with two counts of intoxication manslaughter.
Department of Public Safety spokeswoman Jean Dark said Taylor was travelling the wrong direction when her pickup collided with the van.