Palestinian youths clashed with Israeli forces near the northern entrance of the West Bank city of Hebron, and the soldiers responded with live fire, witnesses said.
"Uday Jihad Irshaid, 22, was killed by live ammunition in his chest during clashes in Hebron," a Palestinian health ministry statement said.
The Israeli military confirmed the use of live rounds but not the fatality.
"A violent riot is taking place in Hebron. Hundreds of Palestinians are attacking forces, hurling rocks and rolling burning tyres at them," an army spokeswoman told AFP.
More From This Section
Irshaid's 17-year-old sister Dania was killed six weeks ago after trying to stab security forces, according to Israeli police.
On the border with the Islamist Hamas-run coastal enclave of Gaza, a Palestinian was shot dead and 12 wounded in clashes with Israeli forces on the other side of the frontier fence.
The Palestinian health ministry said Sami Maadi, 41, died in the incident east of the refugee camp of Al-Bureij.
Earlier today, a 57-year-old was shot dead as he tried to drive his car into a military checkpoint at Halhul, near Hebron, the Israeli army said.
It said that forces present "shot the attacker, resulting in his death", adding that no Israelis were injured in the attack.
Palestinian security sources identified the driver as Issa Haroub from Dir Samat village west of Hebron.
About an hour beforehand, a Palestinian fired at Israeli forces at a crossing between the northern West Bank and Israel and was shot and wounded, the Israeli defence ministry said.
"An armed Palestinian assailant fired shots on the Gilboa crossing from several dozen metres (yards) away," said a statement from the ministry, which employs civilian guards at the site.
The checkpoint is one of the main crossings in the northern area.